WHY ASO TITRE IS NOT RAISED IN AGN

WHY ASO TITRE IS NOT RAISED IN AGN

WHY ASO TITRE IS NOT RAISED IN AGN

ASO and AGN

Anti-streptolysin O (ASO) titre is a measure of the body's immune response to a recent or past infection with Streptococcus pyogenes, also known as group A streptococcus (GAS). ASO titre levels typically rise during an active infection and decrease over time as the infection resolves. On the other hand, antinuclear antibodies (ANA) are a group of antibodies that are directed against various components of the cell nucleus. ANA can be found in the blood of people with autoimmune diseases such as lupus and rheumatoid arthritis.

Why ASO Titre is not Raised in AGN

Antinuclear antibodies (ANA) are a group of antibodies that are directed against various components of the cell nucleus. ANA can be found in the blood of people with autoimmune diseases such as lupus and rheumatoid arthritis. ASO is raised in Streptococcal infections. In AGN there is a deposition of immune complexes formed by DNA, nucleoprotein and anti-DNA, anti-nucleoprotein antibodies in the glomeruli. So in AGN ASO titre is not raised rather ANA titre is raised.

ANA and AGN

ANA can be found in the blood of people with AGN. In fact, ANA positivity is a common finding in patients with AGN, and it is often used as a diagnostic marker for the disease. The presence of ANA in AGN is thought to be due to the body's immune system attacking its own tissues, which leads to the inflammation and damage characteristic of the disease.

Distinguishing between ASO and ANA

ASO and ANA are two different types of antibodies that can be found in the blood. ASO is a type of antibody that is produced by the body in response to an infection with Streptococcus pyogenes, while ANA is a type of antibody that is produced by the body in response to an autoimmune disease such as lupus or rheumatoid arthritis.

When to Test for ASO and ANA

ASO titer testing is typically done when a doctor suspects that a patient has a recent or past infection with Streptococcus pyogenes. ANA testing is typically done when a doctor suspects that a patient has an autoimmune disease.

Treatment for AGN

The treatment for AGN depends on the underlying cause of the disease. If the AGN is caused by an infection, the infection will be treated with antibiotics. If the AGN is caused by an autoimmune disease, the autoimmune disease will be treated with immunosuppressive medications.

Conclusion

ASO titre is not raised in AGN because AGN is not caused by a Streptococcal infection. Rather, ANA titre is raised in AGN because AGN is an autoimmune disease.

FAQs

Q1: What is ASO?


Anti-streptolysin O (ASO) is an antibody that is produced by the body in response to an infection with Group A Streptococcus (GAS) bacteria.

Q2: What is ANA?


Antinuclear antibodies (ANA) are a group of antibodies that are directed against various components of the cell nucleus.

Q3: What is AGN?


AGN stands for Autoimmune Glomerulonephritis, which is a kidney disease caused by the body’s immune system attacking its own kidney tissue.

Q4: Why is ASO titre not raised in AGN?


ASO titre is not raised in AGN because AGN is not caused by a Streptococcal infection.

Q5: What is the treatment for AGN?


The treatment for AGN depends on the underlying cause of the disease. If the AGN is caused by an infection, the infection will be treated with antibiotics. If the AGN is caused by an autoimmune disease, the autoimmune disease will be treated with immunosuppressive medications.

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