WHY DOES BAQSIMI BURN

The Chemistry behind the Combustion of Baqsimi

Baqsimi, a prescription medication used to treat breakthrough cancer pain in adults, is a fentanyl-based nasal spray that can cause a burning sensation in the nose or throat. This burning sensation is caused by fentanyl's physical and chemical properties.

Fentanyl, an opioid analgesic, works by binding to opioid receptors in the brain and spinal cord, blocking pain signals from reaching the brain. However, fentanyl is also a highly lipophilic substance, meaning it easily dissolves in fats and oils. This property enables fentanyl to cross the blood-brain barrier and bind to opioid receptors rapidly.

When Baqsimi is sprayed into the nose, the fentanyl particles come into contact with the nasal mucosa, which is lined with fatty tissue. The fentanyl molecules then dissolve into the fatty tissue and diffuse into the bloodstream, reaching the brain quickly.

The Role of Surfactants

The burning sensation is thought to be caused by the interaction between fentanyl and the surfactants present on the nasal mucosa. Surfactants are molecules that help reduce surface tension and promote the spread of liquids on surfaces. They are also involved in the absorption of drugs through the nasal mucosa.

When Baqsimi is sprayed into the nose, the fentanyl particles come into contact with the surfactants and are dispersed throughout the nasal cavity. The interaction between fentanyl and the surfactants can cause irritation and a burning sensation. The severity of the burning sensation can vary depending on the individual's sensitivity to fentanyl and the concentration of the Baqsimi spray.

Additional Factors Contributing to the Burning Sensation

Alcohol Content

Baqsimi contains alcohol as a solvent. Alcohol is a known irritant and can cause the nasal mucosa to become dry and irritated, which can lead to a burning sensation.

Amount of Dosing

The amount of Baqsimi used can also contribute to the burning sensation. Using a higher dose of Baqsimi can increase the severity of the burning sensation.

Individual Sensitivity

Some people may be more sensitive to fentanyl or other ingredients in Baqsimi, making them more likely to experience a burning sensation.

Underlying Nasal Conditions

People with underlying nasal conditions, such as allergies or rhinitis, may be more prone to experiencing the burning sensation caused by Baqsimi.

Minimizing the Burning Sensation

• Use the lowest effective dose of Baqsimi.
• Avoid using Baqsimi if you have an underlying nasal condition.
• Use a nasal saline spray before using Baqsimi to help reduce irritation.
• Rinse your nose with water after using Baqsimi.
• Talk to your doctor if the burning sensation is severe or persistent.

Conclusion

The burning sensation associated with Baqsimi is typically caused by the interaction between fentanyl and the surfactants in the nasal mucosa. Additional factors, such as alcohol content, dosing amount, and individual sensitivity, can also contribute to the burning sensation. Several strategies can be employed to minimize the burning sensation, including using the lowest effective dose, avoiding use if you have an underlying nasal condition, rinsing the nose with saline before and after use, and discussing alternative options with your healthcare provider.

Frequently Asked Questions

1. Why does Baqsimi burn?

The burning sensation is caused by the interaction between fentanyl and the surfactants in the nasal mucosa.

2. Is the burning sensation harmful?

The burning sensation is usually mild and doesn’t cause any serious health problems. However, if the burning sensation is severe or persistent, talk to your healthcare provider.

3. What can I do to minimize the burning sensation?

You can minimize the burning sensation by using the lowest effective dose, avoiding use if you have an underlying nasal condition, rinsing the nose with saline before and after use, and discussing alternative options with your healthcare provider.

4. Are there any other medications that can cause a burning sensation in the nose?

Yes, other nasal sprays, such as oxymetazoline and phenylephrine, can also cause a burning sensation in the nose.

5. When should I see a doctor about the burning sensation?

You should see a doctor if the burning sensation is severe, persistent, or if you have any other concerns.